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c-myc基因在莫里斯肝癌中的扩增与过表达。

Amplification and over-expression of the c-myc gene in Morris hepatomas.

作者信息

Hayashi K, Makino R, Sugimura T

出版信息

Gan. 1984 Jun;75(6):475-8.

PMID:6468836
Abstract

Morris hepatoma 7794A was found to have its c-myc gene amplified 5- to 10-fold. The over-expression of c-myc was observed in all three hepatomas studied (Morris hepatomas 5123D, 7136A and 7794A), although in the first two instances the c-myc genes were not amplified. Over-expression or deregulation of c-myc seems to be a general phenomenon associated with hepatoma.

摘要

发现莫里斯肝癌7794A的c-myc基因扩增了5至10倍。在所研究的所有三种肝癌(莫里斯肝癌5123D、7136A和7794A)中均观察到c-myc的过表达,尽管在前两种情况下c-myc基因未扩增。c-myc的过表达或失调似乎是与肝癌相关的普遍现象。

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