Meshkinpour H, Mollot M, Eckerling G B, Bookman L
Gastroenterology. 1984 Oct;87(4):759-62.
Unexplained right upper quadrant symptoms have often been attributed to bile duct dyskinesia. In this study we evaluated the pressure profile of the sphincter of Oddi in 10 patients with recurrent episodes of right upper quadrant pain, intermittent mild transaminasemia, and a normal pancreatobiliary tract. Nine healthy volunteers served as control. A triple-lumen catheter with an external diameter of 1.7 mm and recording sites at 2-mm intervals was introduced into the papilla through the endoscope. Ductal pressure, basal sphincter of Oddi pressure, and the amplitude and propagation direction of the phasic contractions of the sphincter were determined in patients and subjects. All measurements were performed relative to duodenal pressure, which was taken as zero. There was no significant difference between patients and subjects in the amplitude and frequency of phasic contractions of sphincter of Oddi. In contrast, the patients demonstrated a higher sphincter of Oddi pressure (p less than 0.005) and increased proportion of retrograde propagation direction of phasic contractions (p less than 0.01). It is concluded that a subpopulation of patients with unexplained abdominal pain demonstrated abnormal pressure profile of the sphincter of Oddi.
不明原因的右上腹症状常常被归因于胆管运动障碍。在本研究中，我们评估了10例右上腹疼痛反复发作、间歇性轻度转氨酶血症且胰胆管正常的患者的Oddi括约肌压力情况。9名健康志愿者作为对照。通过内镜将外径1.7毫米、记录点间隔2毫米的三腔导管插入乳头。测定了患者和受试者的胆管压力、Oddi括约肌基础压力以及括约肌相性收缩的幅度和传播方向。所有测量均相对于十二指肠压力进行，十二指肠压力被视为零。Oddi括约肌相性收缩的幅度和频率在患者和受试者之间无显著差异。相比之下，患者的Oddi括约肌压力更高（p<0.005），相性收缩逆行传播方向的比例增加（p<0.01）。得出的结论是，一部分不明原因腹痛的患者表现出Oddi括约肌压力异常。
