Zeman F J
Growth. 1984 Summer;48(2):234-53.
The effects on growth and reproduction of chronic, moderate multiple deficiencies of protein, riboflavin, pyridoxine and vitamin A were studied in the rat. The effects of combined deficits on feed intake and feed efficiency and on the young were then determined. All deficits, singly or in combination, interfered with the increase in feed efficiency in pregnancy seen in the control rats. Rats fed diets deficient in both protein and vitamin A did not survive to breeding weight. Protein deficiency resulted in reduced number of live young which were of reduced weight. When deficits of riboflavin or pyridoxine or both were also imposed, even fewer live young were produced, but there was no further effect on weights at birth. Reduction in feed intake in pair-fed animals was not totally responsible for these effects. Production of live young was not as depressed by combined vitamin deficiencies when dietary protein was adequate. The most severe effects of any of the deficiencies appeared to occur early in the reproductive process, possibly involving ovulation, embryo survival, implantation and the very early post-implantation period during the development of vital organs. It is suggested that the nutrient deficit interferes with the action of progesterone or other hormones important to the physiological adaptations to pregnancy.
研究了慢性、中度蛋白质、核黄素、吡哆醇和维生素A多种缺乏对大鼠生长和繁殖的影响。然后确定了联合缺乏对采食量、饲料效率以及幼崽的影响。所有单一或联合的缺乏都会干扰对照大鼠孕期饲料效率的提高。喂食蛋白质和维生素A均缺乏日粮的大鼠未能存活到繁殖体重。蛋白质缺乏导致活产幼崽数量减少且体重减轻。当同时存在核黄素或吡哆醇或两者的缺乏时，活产幼崽数量更少，但对出生体重没有进一步影响。成对喂养动物采食量的减少并非这些影响的全部原因。当膳食蛋白质充足时，联合维生素缺乏对活产幼崽的影响没有那么大。任何一种缺乏最严重的影响似乎发生在生殖过程的早期，可能涉及排卵、胚胎存活、着床以及重要器官发育过程中的着床后早期阶段。提示营养缺乏会干扰孕酮或其他对孕期生理适应重要的激素的作用。
