[Effect and tolerance of naproxen. Testing of a new Galenic preparation of an anti-rheumatic agent in an open clinical trial].

The non-steroidal antirheumatic drug naproxen has been available in capsule form since 1974. A new formulation, a film-coated tablet, has recently been developed and has various advantages, namely rapid release and absorption of the active substance, a lower volume, and a score-line. The efficacy and safety of the new tablet in a dose of 1000 mg daily was investigated in 30 patients in an open study. The substance was well tolerated, and there was no need to discontinue treatment in any patient. In the majority of patients the efficacy of the preparation was very good to good. An unsatisfactory effect was only obtained in two cases.