[Intravenous theophylline therapy. Effect of solubilizers on the incidence of adverse local effects in the area of infusion?].

The frequency and intensity of discomfort and pain at the site of injection during intravenous infusion of theophylline sodium glycinate and theophylline ethylenediamine were compared in a single blind crossover study on 6 healthy adult volunteers. The preparation containing theophylline sodium glycinate was significantly better tolerated than theophylline ethylenediamine.