Haeckel R, Terlutter H, Schumann G, Oellerich M
Horm Metab Res. 1984 Aug;16(8):423-7. doi: 10.1055/s-2007-1014807.
Recently hydrazonopropionate derivatives have been recognized as a new group of compounds with strong hypoglycemic effects in various laboratory animals. The hypoglycemia probably has several causes of which an inhibition of gluconeogenesis and of intestinal glucose uptake could be identified. In the present report, the influence of phenylethylhydrazonopropionate, cyclohexylethylhydrazonopropionate, methylcinnamylhydrazonopropionate and their corresponding hydrazine derivatives on the glucose uptake of rat and guinea pig jejunum has been compared with the well known effects caused by phenformin. All substances tested inhibited the jejunal glucose uptake, phenelzine, methylcinnamylhydrazine and cyclohexylhydrazonopropionate more effective, the other compounds less effective than phenformin. The hydrazine derivatives appeared more effective than the hydrazone compounds used. The cellular ATP/ADP ratio was not influenced by the hydrazonopropionate compounds.
最近，肼基丙酸酯衍生物已被公认为是一类在各种实验动物中具有强大降血糖作用的新化合物。低血糖可能有多种原因，其中可以确定的是对糖异生和肠道葡萄糖摄取的抑制作用。在本报告中，已将苯乙基肼基丙酸酯、环己基乙基肼基丙酸酯、甲基肉桂基肼基丙酸酯及其相应的肼衍生物对大鼠和豚鼠空肠葡萄糖摄取的影响与苯乙双胍所产生的众所周知的作用进行了比较。所有测试物质均抑制空肠葡萄糖摄取，苯乙肼、甲基肉桂基肼和环己基肼基丙酸酯的作用更有效，其他化合物的作用比苯乙双胍弱。肼衍生物似乎比所使用的腙化合物更有效。肼基丙酸酯化合物对细胞ATP/ADP比值没有影响。
