Haas J S, Haas C D, Kyle G W
Invest New Drugs. 1984;2(1):3-6. doi: 10.1007/BF00173780.
The B-16 melanoma animal cell line and HEC-1A human endometrial cell line treated with Nafazatrom (NFZ) (5 mu/ml) and varying doses of ionizing radiation show a dose response curve of increased colony inhibition with increasing radiation dose. The B-16 line consistently demonstrated enhanced colony inhibition when NFZ was added prior to radiation. This colony inhibition by NFZ was not seen in the HEC-1A cell line. No adverse effect, i.e., increased tumor colony growth, was evident when NFZ and radiation were combined. This study suggests that ionizing radiation can be combined with NFZ without adverse effect on the cell killing effects of either modality.
用萘呋胺酯（NFZ）（5微克/毫升）和不同剂量的电离辐射处理的B - 16黑色素瘤动物细胞系和HEC - 1A人子宫内膜细胞系显示，随着辐射剂量增加，集落抑制增加的剂量反应曲线。当在辐射前添加NFZ时，B - 16细胞系始终表现出增强的集落抑制。在HEC - 1A细胞系中未观察到NFZ的这种集落抑制作用。当NFZ与辐射联合使用时，没有明显的不良影响，即肿瘤集落生长增加。这项研究表明，电离辐射可以与NFZ联合使用，而不会对任何一种方式的细胞杀伤作用产生不利影响。
