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磷酸吡哆醛诱导的惊厥发作对大鼠脑磷脂代谢的影响。

The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism.

作者信息

Arienti G, Corazzi L, Piccinin G L, Roberti R, Binaglia L, Porcellati G

出版信息

Ital J Neurol Sci. 1984 Jun;5(2):185-8. doi: 10.1007/BF02043221.

Abstract

The intraventricular injection of pyridoxal phosphate (PLP; 1 mumole/brain) to rats causes convulsive seizures beginning 3 min after injection and lasting for about 20 min. The incorporation of [2-3H] glycerol into rat brain glycerides has been studied to ascertain whether treatment with PLP affects the incorporation of label into various lipid classes. The labeling pattern of glycerides is changed by the administration of PLP. The observed alterations begin a few min after injection, together with the convulsive seizures. 1 h after the injection the pattern of labeling of brain glycerides returns to normal. Different glycerides are differently affected by PLP. This work demonstrates that the labeling of diglyceride increases whereas that of phosphatidylethanolamine decreases following PLP administration.

摘要

向大鼠脑室内注射磷酸吡哆醛(PLP;1微摩尔/脑)会在注射后3分钟引发惊厥性癫痫发作,持续约20分钟。研究了[2-³H]甘油掺入大鼠脑甘油酯的情况,以确定PLP处理是否会影响标记物掺入各种脂质类别。PLP给药会改变甘油酯的标记模式。观察到的变化在注射后几分钟开始,与惊厥性癫痫发作同时出现。注射后1小时,脑甘油酯的标记模式恢复正常。不同的甘油酯受PLP的影响不同。这项研究表明,PLP给药后二酰甘油的标记增加,而磷脂酰乙醇胺的标记减少。

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