• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

螺旋霉素的化学修饰。IV. 螺旋霉素I的3'',4''-二酰化物和3,3'',4''-三酰化物的合成及其体外和体内活性

Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3'',4''-diacylates and 3,3'',4''-triacylates of spriamycin I.

作者信息

Sano H, Sunazuka T, Tanaka H, Yamashita K, Okachi R, Omura S

出版信息

J Antibiot (Tokyo). 1984 Jul;37(7):760-72. doi: 10.7164/antibiotics.37.760.

DOI:10.7164/antibiotics.37.760
PMID:6469870
Abstract

3'',4''-Diacylates and 3,3'',4''-triacylates of spiramycin I were synthesized and evaluated by the four parameters, MIC against bacteria, affinity to ribosomes, retention time in HPLC and therapeutic effect. Among them, 3,3'',4''-tri-O-propionyl and 3,4''-di-O-acetyl-3''-O-butyryl-spiramycin I were the most active in vivo, which were superior to acetylspiramycin.

摘要

合成了螺旋霉素I的3'',4''-二酰化物和3,3'',4''-三酰化物，并通过四个参数进行评估，即对细菌的最低抑菌浓度（MIC）、对核糖体的亲和力、在高效液相色谱（HPLC）中的保留时间和治疗效果。其中，3,3'',4''-三-O-丙酰基螺旋霉素I和3,4''-二-O-乙酰基-3''-O-丁酰基螺旋霉素I在体内活性最高，优于乙酰螺旋霉素。

相似文献

1
Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3'',4''-diacylates and 3,3'',4''-triacylates of spriamycin I.螺旋霉素的化学修饰。IV. 螺旋霉素I的3'',4''-二酰化物和3,3'',4''-三酰化物的合成及其体外和体内活性
J Antibiot (Tokyo). 1984 Jul;37(7):760-72. doi: 10.7164/antibiotics.37.760.
2
Structure activity relationships of spiramycins.螺旋霉素的构效关系
J Antimicrob Chemother. 1985 Jul;16 Suppl A:1-11. doi: 10.1093/jac/16.suppl_a.1.
3
Chemical modification of spiramycins. III. Synthesis and antibacterial activities of 4''-sulfonates and 4''-alkylethers of spiramycin I.螺旋霉素的化学修饰。III. 螺旋霉素I的4''-磺酸盐和4''-烷基醚的合成及抗菌活性
J Antibiot (Tokyo). 1984 Jul;37(7):750-9. doi: 10.7164/antibiotics.37.750.
4
Chemical modification of spiramycins. VI. Synthesis and antibacterial activities of 3,3''-di-O-acyl-4''-O-sulfonyl and 3,3''-di-O-acyl-4''-O-alkyl derivatives of spiramycin I.螺旋霉素的化学修饰。VI. 螺旋霉素I的3,3''-二-O-酰基-4''-O-磺酰基和3,3''-二-O-酰基-4''-O-烷基衍生物的合成及抗菌活性
J Antibiot (Tokyo). 1985 Oct;38(10):1350-8. doi: 10.7164/antibiotics.38.1350.
5
Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(Z)-isomers.螺旋霉素的化学修饰。II. 新螺旋霉素I的4'-脱氧衍生物及其12-(Z)-异构体的合成与抗菌活性
J Antibiot (Tokyo). 1984 Jul;37(7):738-49. doi: 10.7164/antibiotics.37.738.
6
Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I.螺旋霉素的化学修饰。I. 新螺旋霉素I缩醛衍生物的合成。
J Antibiot (Tokyo). 1983 Oct;36(10):1336-44. doi: 10.7164/antibiotics.36.1336.
7
Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4''-de-N-methylspiramycin I and their N-substituted derivatives.螺旋霉素的化学修饰。V. 3'-或4''-去-N-甲基螺旋霉素I及其N-取代衍生物的合成与抗菌活性
J Antibiot (Tokyo). 1985 Feb;38(2):186-96. doi: 10.7164/antibiotics.38.186.
8
Chemical modification of tylosin: synthesis of amino derivatives at C-20 position of tylosin and demycarosyltylosin.泰乐菌素的化学修饰：泰乐菌素及去碳霉糖泰乐菌素C-20位氨基衍生物的合成。
J Antibiot (Tokyo). 1983 Dec;36(12):1713-21. doi: 10.7164/antibiotics.36.1713.
9
Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes.柱晶白霉素O-酰基衍生物的构效关系。最低抑菌浓度与结合大肠杆菌核糖体的相关性。
J Med Chem. 1977 May;20(5):732-6. doi: 10.1021/jm00215a025.
10
[Spiramycin derivatives. 1].[螺旋霉素衍生物。1]
Jpn J Antibiot. 1970 Aug;23(4):424-8.

引用本文的文献

1
Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives.新型螺旋霉素酰化衍生物的合成、抗癌及抗菌活性评价
RSC Adv. 2024 Dec 9;14(52):38898-38907. doi: 10.1039/d4ra03126a. eCollection 2024 Dec 3.
2
New directions for macrolide antibiotics: structural modifications and in vitro activity.大环内酯类抗生素的新方向：结构修饰与体外活性
Antimicrob Agents Chemother. 1989 Sep;33(9):1413-8. doi: 10.1128/AAC.33.9.1413.