Sano H, Inoue M, Yamashita K, Okachi R, Omura S
J Antibiot (Tokyo). 1983 Oct;36(10):1336-44. doi: 10.7164/antibiotics.36.1336.
Tetrahydrofuranyl and tetrahydropyranyl derivatives of neospiramycin I at 3 and/or 4' position were synthesized. In vitro and in vivo activities of these derivatives were correlated with the position and configuration of acetal groups. The most effective derivative, 3-a, 4'-a-di-O-tetrahydrofuranylneospiramycin I was comparable to spiramycin I.
合成了新螺旋霉素I在3位和/或4'位的四氢呋喃基和四氢吡喃基衍生物。这些衍生物的体外和体内活性与缩醛基团的位置和构型相关。最有效的衍生物3-α,4'-α-二-O-四氢呋喃基新螺旋霉素I与螺旋霉素I相当。
