Cluzel R A, Lopitaux R, Sirot J, Rampon S
J Antimicrob Chemother. 1984 Jun;13 Suppl C:23-9. doi: 10.1093/jac/13.suppl_c.23.
Rifampicin is a suitable drug for treating staphylococcal bone and articular infections, because high levels are obtained in the human tissues. The best oral dose is 600 mg 12 hourly. The serum levels range from 10 to 15 mg/l at the peak concentration and from 0.2 to 0.6 mg/l 8 h after oral administration of 600 mg. The ratio for cancellous bone/serum is 0.41 at 3 h and 0.39 at 12 h, and for cortical bone/serum is 0.20 at 3 h after a dose of 600 mg. In every case, tissue levels paralleled serum levels; cancellous bone levels are greater than the MIC of Staphylococcus aureus strains until 12 h after a dose of 600 mg. Rifampicin is always used in combination with another antibacterial substance. Results are excellent in most cases. The average duration of antibiotic treatment is 3 months for osteo-arthritis, 6 months for spondylitis and osteitis.
利福平是治疗葡萄球菌骨和关节感染的合适药物，因为它在人体组织中能达到较高浓度。最佳口服剂量是每12小时600毫克。口服600毫克后，峰值浓度时血清水平为10至15毫克/升，8小时后为0.2至0.6毫克/升。服用600毫克剂量后3小时，松质骨/血清比值为0.41，12小时时为0.39；皮质骨/血清比值在3小时时为0.20。在每种情况下，组织水平与血清水平平行；服用600毫克剂量后，直至12小时，松质骨水平均高于金黄色葡萄球菌菌株的最低抑菌浓度。利福平总是与另一种抗菌物质联合使用。大多数情况下效果良好。骨关节炎的抗生素治疗平均持续时间为3个月，脊柱炎和骨炎为6个月。
