Christian M S
J Clin Psychiatry. 1984 Sep;45(9 Pt 2):7-10.
Reproductive toxicology and teratology studies of naltrexone are reviewed. Naltrexone produced behavioral changes in rats at doses below those which affected body weight. Excitatory signs and increased production of seminal plugs occurred in male rats. Prolonged administration to female rats resulted in excitatory signs and impaired maternal activity. Estrus cycling and fertility were decreased in female rats at doses that depressed body weight gain. Higher doses given to pregnant rats for shorter periods of time did not impair fertility or produce embryo or fetal toxicity. In rabbits, there was no evidence of behavioral changes. The highest dosage administered produced transient weight depression and possibly increased resorption. These data are consistent with a report of transient changes in some normal men given single doses of naltrexone. These effects may be mediated via hypothalamic and pituitary mechanisms involved in the control of luteinizing hormone levels.
对纳曲酮的生殖毒理学和致畸学研究进行了综述。纳曲酮在低于影响体重的剂量下可使大鼠出现行为变化。雄性大鼠出现兴奋体征和精栓产生增加。对雌性大鼠长期给药会导致兴奋体征和母性行为受损。在使体重增加受抑的剂量下，雌性大鼠的发情周期和生育力降低。对怀孕大鼠较短时间给予较高剂量并未损害生育力或产生胚胎或胎儿毒性。在兔子中，没有行为变化的证据。所给予的最高剂量导致短暂的体重下降，并可能增加吸收。这些数据与关于一些正常男性单次服用纳曲酮后出现短暂变化的报告一致。这些作用可能通过参与促黄体生成素水平控制的下丘脑和垂体机制介导。
