Yoshida S, Busto R, Santiso M, Ginsberg M D
J Cereb Blood Flow Metab. 1984 Sep;4(3):466-9. doi: 10.1038/jcbfm.1984.66.
The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.
一段缺血期后对大脑进行需氧孵育会引发脂质过氧化。这种效应在维生素E缺乏的大鼠中最为显著，在维生素E正常的大鼠中次之，而在补充了维生素E的动物中最小。相比之下，缺血后进行氮气孵育仅在维生素E缺乏的动物中产生微小影响。似乎再给氧是脂质过氧化物在大脑中积累所必需的。然而，在极度缺血性缺氧期间残留的微量氧气，在维生素E水平较低时，可能足以导致自由基反应的缓慢传播。
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