Iwasa H
Department of Obstetrics and Gynecology, Tokushima University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 May;42(5):422-8.
The effect of dietary vitamin E on the fetal ischemic distress induced by clamping the uterotubal vessels of pregnant rats was studied. The fetal heart rate was measured by the pulsed doppler technique as an index of fetal distress induced by ischemia. On reperfusion after clamping the vessels for 9 min., the decreased fetal heart rate was restored to normal rapidly and completely in the E-supplemented group, but slowly and incompletely in the E-deficient and control groups. On reperfusion after ischemia, the amounts of lipid peroxides, measured as thiobarbituric acid (TBA)-reactive substances, were greatly increased in the fetal brain and liver and in the placenta in the E-deficient and control groups, but not in the E-supplemented group. The vitamin E concentrations in fetal tissues were less than 10% of those in the maternal tissues. But a diet containing a large amount of vitamin E induced significantly increased concentrations of vitamin E in fetal brain and liver. These results suggest that vitamin E may have a protective effect on fetal distress by decreasing lipid peroxides.
研究了膳食维生素E对夹闭孕鼠子宫输卵管血管所致胎儿缺血窘迫的影响。采用脉冲多普勒技术测量胎儿心率，作为缺血诱导胎儿窘迫的指标。血管夹闭9分钟后再灌注时，补充维生素E组胎儿心率下降迅速且完全恢复正常，而维生素E缺乏组和对照组则恢复缓慢且不完全。缺血再灌注后，以硫代巴比妥酸（TBA）反应性物质衡量的脂质过氧化物含量在维生素E缺乏组和对照组的胎儿脑、肝及胎盘中大幅增加，而补充维生素E组未增加。胎儿组织中的维生素E浓度不到母体组织的10%。但含有大量维生素E的饮食可使胎儿脑和肝中的维生素E浓度显著升高。这些结果表明，维生素E可能通过减少脂质过氧化物对胎儿窘迫具有保护作用。
