Perry R, Campbell M, Grega D M, Anderson L
J Clin Psychopharmacol. 1984 Aug;4(4):199-202.
The reliability of saliva lithium levels in monitoring serum lithium levels in children taking lithium has rarely been studied, despite the potential usefulness of such a study and despite a number of adult studies focusing on the technique. In a study of 61 aggressive school-age children diagnosed as undersocialized, aggressive conduct disorder, a subsample of 21 children received lithium. Saliva lithium levels aided in monitoring side effects, and in 15 of the 21 children simultaneous saliva and serum lithium levels were done. These were highly correlated (r = 0.83) and the saliva to serum ratio was 2.53 across subjects. The results indicate that future work with larger numbers of children should study the ratio of saliva to serum lithium levels. Adult studies have shown that there is too great a variability in saliva to serum lithium level ratios to support the use of a fixed saliva to serum lithium ratio. This may not be the case in children. Seventeen children from the lithium subsample experienced 41 lithium-related side effects. Most children suffered side effects on relatively high doses of lithium, and those few who experienced side effects on low dosage had saliva lithium levels that were proportionately high. However, it remains unclear whether saliva lithium can be used to monitor side effects.
尽管此类研究可能有用，且已有多项针对该技术的成人研究，但针对服用锂盐的儿童，通过唾液锂水平监测血清锂水平的可靠性却鲜有研究。在一项针对61名被诊断为社会化不足、攻击性行为障碍的攻击性学龄儿童的研究中，21名儿童的子样本接受了锂盐治疗。唾液锂水平有助于监测副作用，在这21名儿童中，有15名同时进行了唾液和血清锂水平检测。两者高度相关（r = 0.83），受试者的唾液与血清锂水平比值为2.53。结果表明，未来针对更多儿童的研究应探究唾液与血清锂水平的比值。成人研究表明，唾液与血清锂水平的比值变化太大，无法支持使用固定的唾液与血清锂比值。儿童情况可能并非如此。锂盐子样本中的17名儿童出现了41种与锂相关的副作用。大多数儿童在相对高剂量的锂盐治疗时出现副作用，少数在低剂量时出现副作用的儿童，其唾液锂水平也相应较高。然而，唾液锂是否可用于监测副作用仍不明确。
