Kashyap S K, Jani J P, Saiyed H N, Gupta S K
J Environ Sci Health B. 1984 Jun-Jul;19(4-5):479-89. doi: 10.1080/03601238409372445.
Phorate (Thimet), an aliphatic derivative of phosphorus is a highly toxic insecticide. In order to implement the safety measures, the clinical manifestations and cholinesterase (ChE) activity were evaluated before and after 2 weeks of exposure to this insecticide in 40 male formulators. The 2 week's exposure reveal signs and symptoms of toxicity in 60% of the formulators. Gastrointestinal symptoms and lowering of heart rate (bradycardia) were more prominent as compared to the neurological symptoms. A significant depression in plasma ChE activity was observed at the end of 1st week (55%) and 2nd week (71%) as compared to the respective pre-exposure values. A recovery up to 79% of the pre-exposure activity of this enzyme was noticed 10 days after cessation of the above exposure.
甲拌磷（西梅脱）是一种磷的脂肪族衍生物，是一种剧毒杀虫剂。为实施安全措施，对40名男性配方剂调配员在接触这种杀虫剂2周前后的临床表现和胆碱酯酶（ChE）活性进行了评估。2周的接触使60%的配方剂调配员出现中毒迹象和症状。与神经症状相比，胃肠道症状和心率降低（心动过缓）更为突出。与各自接触前的值相比，在第1周末（55%）和第2周末（71%）观察到血浆ChE活性显著降低。在停止上述接触10天后，发现该酶的活性恢复到接触前活性的79%。
