[自由基脂质氧化及用抗坏血酸调节它的几种方式]
[Free radical lipid oxidation and several ways of regulating it with ascorbic acid].
作者信息
Gazdarov A K, Loshkomoeva I N
出版信息
Biofizika. 1978 Mar-Apr;23(2):391-2.
PMID:647053
Abstract
The correlation between the content of primary molecular product of free radical fat acyls oxidation--hydrolipid peroxidation and ascorbic acid amount in guinea-pig tissue was presented by means of polarographic method. The data obtained led to the following conclusion: the importance of ascorbic acid as prooxidant in vivo is rather great and its deficiency is the reason for an increase of its content in the primary products of lipid free radical oxidation, which probably plays the main role in C-avitaminosis pathogenesis.
摘要
采用极谱法研究了豚鼠组织中自由基脂肪酰基氧化的主要分子产物——水解脂质过氧化产物的含量与抗坏血酸含量之间的相关性。所得数据得出以下结论：抗坏血酸在体内作为促氧化剂的重要性相当大，其缺乏是脂质自由基氧化初级产物中抗坏血酸含量增加的原因，这可能在维生素C缺乏病的发病机制中起主要作用。
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