Patterson R, Bernstein P R, Harris K E, Krell R D
J Lab Clin Med. 1984 Sep;104(3):340-5.
Leukotriene D4 and synthetic platelet-activating factor have been shown to qualitatively reproduce an antigen-induced airway response in rhesus monkeys at concentrations several hundred times less than histamine. In normal rhesus monkeys, challenges with concentrations of leukotriene D4 or platelet-activating factor, established as subthreshold doses (not producing a response), result in abnormal pulmonary function parameters when followed by a second challenge of a subthreshold dose. Results were similar with any sequence of leukotriene D4 and platelet-activating factor combination. This was not a result of additive effects of agonists, because previous experiments have shown that log or 0.5 log increases over the subthreshold dose are necessary for a response. Our results may suggest that these mediators that possess remarkable biologic activity might sensitize the lower airway for response to stimulation with the same or other mediators.
白三烯D4和合成血小板活化因子已被证明，在恒河猴中，其浓度比组胺低数百倍时，就能定性地重现抗原诱导的气道反应。在正常恒河猴中，用确定为阈下剂量（不产生反应）的白三烯D4或血小板活化因子浓度进行激发，随后再用阈下剂量进行第二次激发时，会导致肺功能参数异常。白三烯D4和血小板活化因子组合的任何顺序，结果都是相似的。这不是激动剂加和作用的结果，因为先前的实验表明，要产生反应，需要在阈下剂量基础上增加对数或0.5对数。我们的结果可能表明，这些具有显著生物活性的介质可能会使下呼吸道对相同或其他介质的刺激产生敏感反应。
