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肌营养不良小鼠脊髓神经根和坐骨神经中的髓磷脂蛋白与胶原蛋白

Myelin proteins and collagen in the spinal roots and sciatic nerves of muscular dystrophic mice.

作者信息

John H A, Purdom I F

出版信息

J Neurol Sci. 1984 Jul;65(1):69-80. doi: 10.1016/0022-510x(84)90068-6.

DOI:10.1016/0022-510x(84)90068-6
PMID:6470746
Abstract

Proteins of lumbosacral spinal roots and sciatic nerves of adult dystrophic mice (Bar Harbor 129REJ dydy) were analyzed by SDS gel electrophoresis to determine if identifiable proteins were affected. All peripheral nerve myelin proteins (P0 glycoprotein, P1 and Pr basic proteins, X protein and a high-molecular-weight protein) were decreased in the roots but not in the sciatic nerves. Central nervous system myelin proteins were not increased in either roots or sciatic nerves. Although dystrophic spinal roots and sciatic nerves contained less collagen, Type I, III and V collagens were present.

摘要

通过SDS凝胶电泳分析成年营养不良小鼠(巴港129REJ dydy)腰骶部脊神经根和坐骨神经的蛋白质,以确定是否有可识别的蛋白质受到影响。所有周围神经髓磷脂蛋白(P0糖蛋白、P1和Pr碱性蛋白、X蛋白和一种高分子量蛋白)在神经根中减少,但在坐骨神经中未减少。中枢神经系统髓磷脂蛋白在神经根和坐骨神经中均未增加。虽然营养不良的脊神经根和坐骨神经中的胶原蛋白含量较少,但I型、III型和V型胶原蛋白均存在。

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