Perkins C S, Bray G M, Aguayo A J
Brain Res. 1981 Apr;227(2):213-20. doi: 10.1016/0165-3806(81)90109-7.
In the spinal roots of dystrophic mice, there are bundles of unensheathed axons and two populations of axon-associated cells: the typical Schwann cells of myelinated fibers and 'uncommitted' cells at the margin of the bundles. Because these 'uncommitted' cells continue to divide in adult animals but fail to ensheath the axons they appose, they can be labelled with tritiated thymidine. In the present experiments, we show that these cells may differentiate into typical Schwann cells of myelinated or unmyelinated fibers when spinal roots from [3H]thymidine-labelled dystrophic mice are grafted into the sciatic nerves of non-dystrophic animals. Thus, this study demonstrates that the 'uncommitted' cells of dystrophic spinal roots are undifferentiated Schwann cells whose differentiation in the intact spinal roots is continuously prevented by some unknown mechanism.
在营养不良小鼠的脊神经根中，存在成束的无髓鞘轴突以及两类与轴突相关的细胞：有髓纤维的典型施万细胞和成束边缘的“未分化”细胞。由于这些“未分化”细胞在成年动物中持续分裂，但未能包绕它们所接触的轴突，所以可用氚标记的胸腺嘧啶核苷对其进行标记。在本实验中，我们发现，当将来自用[³H]胸腺嘧啶核苷标记的营养不良小鼠的脊神经根移植到非营养不良动物的坐骨神经中时，这些细胞可能会分化为有髓或无髓纤维的典型施万细胞。因此，本研究表明，营养不良脊神经根中的“未分化”细胞是未分化的施万细胞，其在完整脊神经根中的分化受到某种未知机制的持续抑制。
