Cao M, Lisheng H, Shouzheng S
J Neurosurg. 1984 Oct;61(4):707-12. doi: 10.3171/jns.1984.61.4.0707.
A series of 87 patients with severe brain injury were studied. Intracranial pressure (ICP) monitoring and external ventricular drainage were used to control ICP at high and low levels. Clearance of ytterbium-169-labeled diethylenetriaminepentaacetic acid (169Yb-DTPA), Evans blue dye, and ventricular cerebrospinal fluid protein was measured at the two ICP levels over consecutive periods of 4 hours to confirm clearance of brain edema. The results support the hypothesis that brain edema is in part absorbed in the cerebrospinal fluid via transventricular flow.
对87例重型颅脑损伤患者进行了研究。采用颅内压（ICP）监测和脑室外引流来控制ICP的高低水平。在连续4小时的两个ICP水平上，测量了镱-169标记的二乙三胺五乙酸（169Yb-DTPA）、伊文思蓝染料和脑室脑脊液蛋白的清除率，以确认脑水肿的清除情况。结果支持了脑水肿部分通过脑室间流动在脑脊液中被吸收的假说。
