Klein H A, Wald A
J Nucl Med. 1984 Sep;25(9):957-64.
For detailed examination of the esophageal transit of a swallowed radioactive liquid bolus, three computer-based techniques have been developed: (a) analysis of time-activity curves with decomposition into rapid and residual components, yielding the mean transit time for the former and the residual fraction for the latter; (b) reduction of dynamic image sequences to single condensed images, facilitating subjective assessment; and (c) tracking of the centroid of radioactivity, permitting quantification of retrograde motion. Studies were performed on 12 normal subjects and on six patients with motility disorders. Elevated residual fractions were observed in all the patients, and an abnormal degree of retrograde motion in two. Two normal and two abnormal studies exemplify the variety of patterns observed in condensed images.
为了详细检查吞咽放射性液体团块的食管通过情况，已开发出三种基于计算机的技术：(a) 分析时间-活性曲线，将其分解为快速和残留成分，得出前者的平均通过时间和后者的残留分数；(b) 将动态图像序列简化为单个浓缩图像，便于主观评估；(c) 跟踪放射性质心，从而对逆行运动进行量化。对12名正常受试者和6名运动障碍患者进行了研究。所有患者均观察到残留分数升高，两名患者出现异常程度的逆行运动。两个正常研究和两个异常研究例证了在浓缩图像中观察到的各种模式。
