Davis M G, Manners C N, Payling D W, Smith D A, Wilson C A
J Pharm Sci. 1984 Jul;73(7):949-53. doi: 10.1002/jps.2600730722.
Gastrointestinal absorption of the strongly acidic drug proxicromil has been studied with respect to its physical organic chemistry. The lipophilicity of the drug above pH 6 in octanol-buffer partition experiments is dependent on ion pair formation. Similar trends were demonstrated for the in vitro partition of the compound into GI tissue. The absorption of the compound from the perfused GI tract of rats in vivo was not consistent with classical un-ionized drug absorption theories and indicated the operation of other processes, especially ion pair formation, as major mechanisms of proxicromil absorption.
已从物理有机化学角度研究了强酸性药物色甘丙脯的胃肠道吸收情况。在辛醇 - 缓冲液分配实验中，该药物在pH 6以上的亲脂性取决于离子对的形成。该化合物在体外向胃肠道组织的分配也呈现出类似趋势。该化合物在大鼠体内经灌注胃肠道的吸收情况与经典的非离子化药物吸收理论不一致，这表明存在其他过程，尤其是离子对的形成，是色甘丙脯吸收的主要机制。
