Kennedy J A, de la Lande I S
Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun;326(2):143-7. doi: 10.1007/BF00517311.
The metabolites of (-)-3H-noradrenaline (1.2 mumol l-1) formed by uteri from non-pregnant mature rabbits were, in descending order of importance, 3H-DOPEG greater than 3H-MOPEG greater than 3H-NMN greater than 3H-VMA (3H-DOMA not measured). The pattern of metabolite formation per unit mass of tissue was markedly different in uteri from 28 day pregnant rabbits due to a fourfold increase in 3H-NMN formation and a fourfold decrease in 3H-DOPEG formation. The effects of cocaine indicated that 3H-NMN was largely extraneuronal in origin and 3H-DOPEG was both neuronal and extraneuronal in origin. The pattern of metabolite formation in pregnant rabbit uteri closely resembled the reported pattern in uteri from ovariectomized rabbits treated with 17 beta-oestradiol and progesterone. In the rabbit oviduct and ovary, the patterns of metabolite formation, and their modification by cocaine, indicated that (-)-3H-noradrenaline was metabolised mainly by intraneuronal deamination in the oviduct and mainly by extraneuronal O-methylation in the ovary. Pregnancy did not affect (-)-3H-noradrenaline metabolism in the oviduct, but decreased the metabolism in the ovary.
未孕成熟兔子宫形成的（-）-3H-去甲肾上腺素（1.2 μmol l-1）代谢产物，按重要性降序排列为：3H-DOPEG＞3H-MOPEG＞3H-NMN＞3H-VMA（未测定3H-DOMA）。由于3H-NMN生成增加四倍且3H-DOPEG生成减少四倍，28天妊娠兔子宫中每单位组织的代谢产物形成模式明显不同。可卡因的作用表明，3H-NMN主要起源于神经外，而3H-DOPEG起源于神经内和神经外。妊娠兔子宫中的代谢产物形成模式与报道的用17β-雌二醇和孕酮处理的去卵巢兔子宫中的模式非常相似。在兔输卵管和卵巢中，代谢产物形成模式及其受可卡因的影响表明，（-）-3H-去甲肾上腺素在输卵管中主要通过神经内脱氨代谢，在卵巢中主要通过神经外O-甲基化代谢。妊娠不影响输卵管中（-）-3H-去甲肾上腺素的代谢，但会降低卵巢中的代谢。
