Sun Q X, Zhang J, Ji Q M, Wang Y C, Xie D F, Hua R L, He W Y, Shi X C, Li Y J, Jiang C J
Nuklearmedizin. 1984 Apr;23(2):73-4.
123I- and 131I-labeled hexadecenoic acid (IHDA, radiochemical purity over 92%, dissolved in 6% bovine serum albumin solution) was investigated in vivo. ICR mice were administered IHDA via the tail vein. Maximum myocardial uptake (27.3 +/- 5.1%) was reached about 0.5 min after the injection. The ratio of uptake in the heart to that in the lungs was 2.3, to that in liver 1.5 and to that in other organs 2.4 to 6.4. The dog myocardium was visualized distinctly within 3-5 min with a gamma camera after i.v. 131I-IHDA, and not interfered with by activities in the lungs, liver and other organs. The low blood levels at 20 min had little effect on the quality of the heart images.
对123I和131I标记的十六碳烯酸（IHDA，放射化学纯度超过92%，溶解于6%牛血清白蛋白溶液）进行了体内研究。通过尾静脉给ICR小鼠注射IHDA。注射后约0.5分钟达到最大心肌摄取量（27.3±5.1%）。心脏与肺的摄取比为2.3，与肝脏的摄取比为1.5，与其他器官的摄取比为2.4至6.4。静脉注射131I - IHDA后，用γ相机在3 - 5分钟内可清晰显示犬心肌，且不受肺、肝和其他器官放射性的干扰。20分钟时的低血药浓度对心脏图像质量影响很小。
