Sun Q X, Ji Q M, Wang Y C, Zhang J, Shi X C, Wang Y, Zhau Z T, In L X, Ye Y F, Chen S Y
Nuklearmedizin. 1984 Apr;23(2):75-6.
11C-benzoic acid prepared in a radiochemical purity over 90% was studied radiopharmacologically in mice and rabbits. The uptake of 11C-benzoate in ICR mice increased quickly. The ratio of kidney uptake rate to that in other organs reached values between 9 and 55 with a maximum at 10 min after i.v. injection. Gamma camera imaging of rabbits showed that uptake in the kidneys began at 2 min after injection and that activity began to appear in the bladder 4 min later. Rabbits with left renal artery ligature showed no uptake in the left kidney but the right kidney was imaged to the same extent as that of a rabbit without artery ligature. The kidney imaging of 11C-benzoic acid may be a useful method for renal diagnosis.
对放射化学纯度超过90%的11C-苯甲酸在小鼠和兔子身上进行了放射药理学研究。11C-苯甲酸盐在ICR小鼠体内的摄取迅速增加。静脉注射后10分钟时，肾脏摄取率与其他器官摄取率的比值达到9至55之间，在10分钟时达到最大值。对兔子进行γ相机成像显示，注射后2分钟开始在肾脏摄取，4分钟后膀胱开始出现放射性。左肾动脉结扎的兔子左肾无摄取，但右肾成像程度与未进行动脉结扎的兔子相同。11C-苯甲酸的肾脏成像可能是一种有用的肾脏诊断方法。
