Stirrat G M, Redman C W, Levinsky R J
Br Med J. 1978 Jun 3;1(6125):1450-1. doi: 10.1136/bmj.1.6125.1450.
Sixteen patients with severe pre-eclampsia had more IgG-containing and C1q-binding circulating soluble immune complexes than did 16 matched women with normal pregnancies. The clinical features of preeclampsia may be explained by damage due to such complexes, although raised complex levels were also present in a few women with normal pregnancies. As immune complexes are so heterogenous in terms of the type of antigen, class and subclass of immunoglobulin, size, and complement-binding capacity, further investigations are needed to determine their role in normal and pre-eclamptic pregnancies.
16例重度子痫前期患者比16例匹配的正常妊娠女性含有更多的IgG及结合C1q的循环可溶性免疫复合物。子痫前期的临床特征可能由这类复合物造成的损伤所解释，尽管少数正常妊娠女性中也存在免疫复合物水平升高的情况。由于免疫复合物在抗原类型、免疫球蛋白的类别和亚类、大小及补体结合能力方面存在很大差异，因此需要进一步研究以确定它们在正常妊娠和子痫前期妊娠中的作用。
