Redman C W, Denson K W, Beilin L J, Bolton F G, Stirrat G M
Lancet. 1977 Dec 17;2(8051):1249-52. doi: 10.1016/s0140-6736(77)92661-7.
In 50 women with high-risk pregnancies, increased factor-VII consumption, as estimated by the difference between the levels of factor-VIII-related antigen and factor-VIII clotting activity, correlated with the severity of pre-eclampsia, particularly when measured by increases in plasma-urate. Longitudinal studies of the evolution of pre-eclampsia demonstrated that increased factor-VIII consumption usually but not always developed before hyperuricaemia. The earliest time that abnormal factor-VIII consumption was demonstrated was at 18 weeks' gestation in a woman who had had two previous stillbirths. Subcutaneous heparin and oral dipyridamole failed to reverse the coagulation abnormality, and the fetus died in utero at 28 weeks' gestation. The renal and coagulation changes characteristic of pre-eclampsia were also seen in a patient without hypertension. This suggests that the concept of pre-eclampsia may need to be widened to include a non-hypertensive syndrome characterised by these changes in clotting and renal function.
在50例高危妊娠女性中，通过因子VIII相关抗原水平与因子VIII凝血活性之间的差异估算的因子VII消耗增加，与子痫前期的严重程度相关，尤其是当通过血浆尿酸盐升高来衡量时。对子痫前期演变的纵向研究表明，因子VIII消耗增加通常但并非总是在高尿酸血症之前出现。最早发现异常因子VIII消耗的时间是在一名有两次死产史的女性妊娠18周时。皮下注射肝素和口服双嘧达莫未能逆转凝血异常，胎儿在妊娠28周时死于宫内。在一名无高血压的患者中也观察到了子痫前期典型的肾脏和凝血变化。这表明子痫前期的概念可能需要拓宽，以包括一种以凝血和肾功能这些变化为特征的非高血压综合征。
