用针对主要透明带蛋白ZP-2的单克隆抗体对正常小鼠卵巢进行闪烁扫描。
Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein.
作者信息
East I J, Keenan A M, Larson S M, Dean J
出版信息
Science. 1984 Aug 31;225(4665):938-41. doi: 10.1126/science.6474160.
PMID:6474160
Abstract
The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.
摘要
透明带是一种细胞外糖萼，由三种硫酸化糖蛋白组成，围绕着哺乳动物的卵母细胞。对最丰富的透明带蛋白ZP-2具有特异性的经肠胃外给药的单克隆抗体定位于透明带。当用碘-125标记时，这些单克隆抗体显示出非常高的靶组织与非靶组织比率，并能提供清晰的卵巢组织外部放射性成像。
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