Leonard R J, Nakajima S, Nakajima Y, Takahashi T
Science. 1984 Oct 5;226(4670):55-7. doi: 10.1126/science.6474189.
Physiological properties of acetylcholine receptors on muscle cells at very early stages of ontogeny were compared with those of cells at later stages. Two changes were observed that contributed to an overall shortening of the mean open time of single-channels. First, there was a shift in the relative proportions of two receptor types with different conductances and mean open times, such that the contribution of receptors with large conductance and short open time increased as development proceeded. Second, there was a sharp reduction in the mean open time of channels having small conductance, with no similar change in channels having large conductance.
将个体发育非常早期阶段肌肉细胞上乙酰胆碱受体的生理特性与后期阶段细胞的生理特性进行了比较。观察到两个变化，这两个变化导致单通道平均开放时间总体缩短。首先，两种具有不同电导和平均开放时间的受体类型的相对比例发生了变化，随着发育的进行，具有高电导和短开放时间的受体的贡献增加。其次，小电导通道的平均开放时间急剧缩短，而大电导通道没有类似变化。
