Asymmetrical limb reduction deformities--aetiological considerations.

The clinical features of a newborn female infant with reduction deformities of three limbs and no additional major malformations are presented. Diagnostic precision is crucial for accurate prognostication since both genetic and non-genetic causes have to be considered in such instances. The main differential diagnosis in our patient included a number of specific inherited disorders of which limb reduction is a component, as well as the consequences of both early amniotic rupture and fetal vascular disruption. We favoured the latter and concluded that the risk of recurrence was minimal. The approach to limb reduction disorders should be individualized.