Lever A M, Corris P A, Gibson G J
Thorax. 1984 Aug;39(8):576-8. doi: 10.1136/thx.39.8.576.
Ten male asthmatic volunteers each inhaled two puffs (200 micrograms) of salbutamol on two separate days 30 minutes after double blind oral administration of either 20 mg nifedipine or identical placebo. FEV1 was recorded before and at intervals for four hours after inhalation of salbutamol. Overall the FEV1 was significantly greater during the four hour period after premedication with nifedipine (p less than 0.025) and the difference between the effects of placebo and nifedipine was greatest four hours after salbutamol (p less than 0.005). These results suggest that nifedipine prolongs the bronchodilator action of salbutamol in vivo.
十名男性哮喘志愿者在双盲口服20毫克硝苯地平或相同安慰剂30分钟后的两天，分别吸入两喷（200微克）沙丁胺醇。在吸入沙丁胺醇之前及之后的四小时内每隔一段时间记录第一秒用力呼气量（FEV1）。总体而言，硝苯地平预处理后的四小时内FEV1显著更高（p<0.025），安慰剂和硝苯地平作用之间的差异在吸入沙丁胺醇后四小时最大（p<0.005）。这些结果表明硝苯地平在体内可延长沙丁胺醇的支气管扩张作用。
