Sugiyama M, Sasaki H, Inoue H, Nakamura M, Sasaki T, Takishima T
Tohoku J Exp Med. 1984 Jun;143(2):197-204. doi: 10.1620/tjem.143.197.
About 100 beads, 2 mm in diameter were wedged into the small airways of excised dog lungs. Pulmonary function tests were performed in the lungs before and after the obstruction of the small airway with beads. Of the pulmonary function tests performed, lung pressure-volume curve, lung resistance-lung volume relationship, frequency dependency of dynamic compliance, closing volume, and N2 multiwashout curve did not show any significant alteration after small airway obstruction. Only the flow-volume curve at low lung volume showed any significant alteration. This suggests that the flow-volume curve is the most sensitive pulmonary function test in the detection of early obstructive impairment of the small airways.
将约100颗直径为2毫米的珠子楔入切除的犬肺小气道中。在用珠子阻塞小气道前后，对肺进行了肺功能测试。在所进行的肺功能测试中，肺压力-容积曲线、肺阻力-肺容积关系、动态顺应性的频率依赖性、闭合容积和氮气多次冲洗曲线在小气道阻塞后均未显示出任何显著变化。只有低肺容积时的流量-容积曲线显示出显著变化。这表明流量-容积曲线是检测小气道早期阻塞性损害最敏感的肺功能测试。
