Neugebauer A
Z Gesamte Inn Med. 1984 Jun 1;39(11):249-52.
Since there are no antiarrhythmic drugs with selective effect on the removal of pathologic rhythms without influence on the formation of normal stimuli and the conduction system, which are free from cardiac and extracardiac side effects, in the application of an antiarrhythmic drug apart from an indication which is strictly to be established it must equivalently be taken into consideration which systemic and genuine side effects, pharmacokinetic problems and drug interactions must be taken into account. An unavoidable risk (systemic side effects) is to be put up with. Existing contraindications sometimes bring about the renunciation of therapy. Side effects are avoidable, when they are strictly controlled, since they are then recognized in time and lead to the interruption of therapy.
由于不存在对消除病理性节律有选择性作用而不影响正常刺激形成和传导系统、且无心脏和心外副作用的抗心律失常药物，在应用抗心律失常药物时，除了必须严格确定的适应症外，还必须同等考虑哪些全身和真正的副作用、药代动力学问题以及药物相互作用需要考虑。必须忍受不可避免的风险（全身副作用）。现有的禁忌症有时会导致放弃治疗。当副作用得到严格控制时是可以避免的，因为此时能及时识别并导致治疗中断。
