Harrison D C
Arch Mal Coeur Vaiss. 1981 Dec;74 Spec No:65-72.
Tables 3 and 4 summarize the important pharmacokinetic characteristics of commonly-used antiarrhythmic agents. Pharmacokinetic principles are just as important to the clinician as they are to pharmacologists. For the pharmacologist they define the time course of processes involved in the absorption, distribution, metabolism and elimination of drugs. For the clinician they provide basis for administering drugs to patients with disease processes which require a specific agent. Plasma concentration is generally related to efficacy and safety for many antiarrhythmic drugs and understanding the principles related to drug concentration in individual patients is necessary for rational use of many cardioactive agents. This paper provides an approach for the clinician to utilize the basic concepts of pharmacokinetics in practice.
表3和表4总结了常用抗心律失常药物的重要药代动力学特征。药代动力学原理对临床医生和药理学家同样重要。对药理学家而言，它们定义了药物吸收、分布、代谢和消除过程的时间进程。对临床医生而言，它们为给患有需要特定药物的疾病过程的患者用药提供了依据。对于许多抗心律失常药物，血浆浓度通常与疗效和安全性相关，了解个体患者药物浓度相关原理对于合理使用许多心血管活性药物是必要的。本文为临床医生在实践中运用药代动力学基本概念提供了一种方法。
