Matzen K A, Brückl R, Knolle P
Z Orthop Ihre Grenzgeb. 1984 May-Jun;122(3):320-8. doi: 10.1055/s-2008-1044634.
PVP-iodine was applied in this pilot study as irrigation solution containing 0.2% active ingredient for irrigation-suction drainage. It was well tolerated. The degree of iodine absorption remained within a lower region encountered with commonly available iodine-containing medications. Increased iodine levels returned to normal ranges soon after termination of treatment. Changes in thyroxine values were without clinical symptoms. No hypothyreosis was encountered. In spite of this it is recommended to control thyroid function before, during and after irrigation treatment with PVP-I in patients with a possible disposition for iodine-induction of thyroid function. Pregnancy (after the third month) and the presence of autonomous adenomas of the thyroid are contraindications because of the iodine load encountered. Palpable evidence for a thyroid enlargement is also a contraindication, except when the patient had not responded with thyroidal side reactions after prior exposure to iodine-containing contrast agents. During the irrigation treatment with PVP-I wounds became free of microorganisms. Local irritations due to the application of PVP-I were rare. The patient acceptance was excellent or good.
在这项初步研究中，聚乙烯吡咯烷酮碘作为含0.2%活性成分的冲洗液用于冲洗吸引引流。它耐受性良好。碘吸收程度保持在常用含碘药物所遇到的较低范围内。治疗结束后不久，碘水平升高便恢复到正常范围。甲状腺素值的变化无临床症状。未出现甲状腺功能减退。尽管如此，对于可能因碘诱导甲状腺功能的患者，建议在用聚乙烯吡咯烷酮碘冲洗治疗前、治疗期间和治疗后监测甲状腺功能。由于碘负荷，怀孕（第三个月后）和甲状腺自主腺瘤的存在是禁忌证。甲状腺肿大的明显证据也是禁忌证，除非患者在先前接触含碘造影剂后未出现甲状腺副作用。在用聚乙烯吡咯烷酮碘冲洗治疗期间，伤口无微生物。因使用聚乙烯吡咯烷酮碘引起的局部刺激很少见。患者接受度极佳或良好。
