Takeuchi S, Gotoh S, Tari K, Kanda Y, Ishii M, Fujiwara M
Hinyokika Kiyo. 1984 May;30(5):671-8.
There have been very few reports on renal malignancies in tuberous sclerosis and only 9 cases have been reported in the Japanese literature. A second case of renal cell carcinoma in tuberous sclerosis in Japan is reported. The present case is a 29-year-old male who visited our clinic with the chief complaint of right flank mass. The excretory urogram, and renal selective angiography suggested right benign renal tumor, possibly angiomyolipoma. But surgical exploration was performed because of the possibility of renal malignancy. The histological findings revealed renal cell carcinoma. At 18 months after operation, the patient died of multiple visceral metastasis, i.e., to lungs, left kidney and liver. In this case basic fetoprotein - a new carcinoembryonic protein - was measured and its level elevated gradually as the disease progressed. Judging from the measurement of basic fetoprotein in this patient it may be an efficient new tumor marker for renal cell carcinoma.
关于结节性硬化症合并肾恶性肿瘤的报道非常少，日本文献中仅报道过9例。本文报道了日本第二例结节性硬化症合并肾细胞癌的病例。该病例为一名29岁男性，因右侧腰部肿块为主诉前来我院就诊。排泄性尿路造影和肾选择性血管造影提示右侧良性肾肿瘤，可能为血管平滑肌脂肪瘤。但由于存在肾恶性肿瘤的可能性，故进行了手术探查。组织学检查结果显示为肾细胞癌。术后18个月，患者死于多脏器转移，即肺、左肾和肝脏转移。在该病例中，检测了一种新的癌胚蛋白——碱性胎蛋白，其水平随着疾病进展而逐渐升高。从该患者碱性胎蛋白的检测结果判断，它可能是一种有效的肾细胞癌新肿瘤标志物。
