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急性心肌梗死后室内传导障碍患者永久性起搏的伯明翰试验

The Birmingham Trial of permanent pacing in patients with intraventricular conduction disorders after acute myocardial infarction.

作者信息

Watson R D, Glover D R, Page A J, Littler W A, Davies P, de Giovanni J, Pentecost B L

出版信息

Am Heart J. 1984 Sep;108(3 Pt 1):496-501. doi: 10.1016/0002-8703(84)90414-9.

DOI:10.1016/0002-8703(84)90414-9
PMID:6475712
Abstract

Patients surviving 2 weeks after myocardial infarction who had persistent conduction disorder (right bundle branch block alone or associated with left anterior or posterior hemiblock [LPH] or LPH alone) were allocated at random to permanent pacing or control groups. Throughout follow-up, up to 5 years, there was no significant difference in survival: at 2 years 14 of 23 (61%) of paced patients had died compared with 11 of 27 (41%) control patients. Progression of conduction disorder was not observed and measurement of infranodal conduction time (HV interval) did not predict outcome. Ventricular tachyarrhythmias were an important cause of death in these patients and pacing appears to offer no benefit.

摘要

心肌梗死后存活2周且患有持续性传导障碍(单独右束支传导阻滞或合并左前或左后半束支传导阻滞[LPH]或单独LPH)的患者被随机分配到永久起搏组或对照组。在长达5年的随访期间,两组生存率无显著差异:2年后,23例接受起搏治疗的患者中有14例(61%)死亡,而27例对照组患者中有11例(41%)死亡。未观察到传导障碍的进展,节下传导时间(HV间期)的测量也无法预测预后。室性快速心律失常是这些患者死亡的重要原因,起搏治疗似乎并无益处。

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