Parant M, Riveau G, Parant F, Chedid L
Am J Physiol. 1984 Sep;247(3 Pt 1):C169-74. doi: 10.1152/ajpcell.1984.247.3.C169.
N-acetylmuramyl-L-alanyl-D-isoglutamine, or muramyl dipeptide (MDP), is a synthetic immunoadjuvant analogue of a bacterial peptidoglycan subunit that has a definite pyrogenic effect in the rabbit. Some adjuvant-active derivatives such as murabutide [MDP(Gln)-OnBu] or murametide [MDP(Gln)-OMe] are not pyrogenic. Murabutide did not stimulate human or rabbit cells to release endogenous pyrogen (EP), but murametide induced EP production at the same dosage levels as MDP. Moreover, plasma from rabbits treated with murametide transferred into untreated recipients elicited a febrile response typical of EP fever and comparable with that induced by plasma from MDP-treated animals. Murametide not only inhibited the central effect of EP that is generated but also the effect of an extra dose of EP administered later by the intravenous route. Moreover, pretreatment of rabbits with murametide decreased fever responses induced by certain high-molecular-weight exogenous pyrogens as mediated through the production of EP.
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺，即胞壁酰二肽（MDP），是一种细菌肽聚糖亚基的合成免疫佐剂类似物，对兔子有明确的致热作用。一些具有佐剂活性的衍生物，如murabutide [MDP(Gln)-OnBu] 或murametide [MDP(Gln)-OMe] 则无致热作用。Murabutide不会刺激人或兔细胞释放内源性致热原（EP），但murametide在与MDP相同的剂量水平下可诱导EP产生。此外，用murametide处理过的兔子的血浆转移到未处理的受体中会引发典型的EP热发热反应，且与MDP处理动物的血浆所诱导的反应相当。Murametide不仅抑制所产生的EP的中枢作用，还抑制随后静脉注射额外剂量EP的作用。此外，用murametide对兔子进行预处理可降低某些高分子量外源性热原通过EP产生介导的发热反应。
