Seow L T, Mather L E, Cousins M J
Anaesth Intensive Care. 1984 May;12(2):127-30. doi: 10.1177/0310057X8401200208.
The efficacy of intravenous atropine in abolishing the nasal irritation of chlormethiazole was assessed. Forty elderly patients undergoing transurethral resection of prostate under spinal anaesthesia were studied. One ml of either atropine sulphate (0.6 mg) or normal saline was administered intravenously in a double-blind fashion 10 minutes prior to infusion of 0.8% chlormethiazole edisylate. A loading infusion of 5 ml X min-1 of the chlormethiazole solution was followed by a variable rate of infusion in order to maintain a predetermined state of sedation--i.e. where the patient lapsed into sleep but was easily awakened to obey commands. Sneezing was the commonest side-effect occurring in 45% and 70% of patients in atropine and saline groups respectively. This was not effectively abolished by IV atropine in incremental doses of 0.6 mg up to 1.8 mg. Because of the sneezing and restlessness, four patients in the atropine group required general anaesthesia to improve operating conditions. These side-effects of chlormethiazole may limit its use as a sedative for surgery in this elderly age group.
评估了静脉注射阿托品消除氯美噻唑所致鼻刺激的疗效。对40例在脊髓麻醉下接受经尿道前列腺切除术的老年患者进行了研究。在输注0.8% 乙磺半胱氨酸氯美噻唑前10分钟，以双盲方式静脉注射1ml硫酸阿托品（0.6mg）或生理盐水。先以5ml·min⁻¹ 的速率静脉输注氯美噻唑溶液进行负荷输注，然后以可变速率输注，以维持预定的镇静状态，即患者入睡但易于唤醒以听从指令。打喷嚏是最常见的副作用，分别在阿托品组和生理盐水组中45% 和70% 的患者中出现。静脉注射剂量递增至1.8mg的阿托品并不能有效消除打喷嚏。由于打喷嚏和躁动不安，阿托品组有4例患者需要全身麻醉以改善手术条件。氯美噻唑的这些副作用可能会限制其在该老年年龄组手术中作为镇静剂的应用。
