Abramson D C
Department of Anesthesiology, University of Texas Houston 77030, USA.
Can J Anaesth. 1995 Aug;42(8):740-3. doi: 10.1007/BF03012675.
The author presents a case report where, following propofol sedation for a peribulbar block, sneezing was induced once the local anaesthetic needle was placed in the orbital cavity. The physiology of sneezing is discussed, as well as the pathophysiology of the ACHOO (Autosomal Dominant Compelling Helio-Ophthalmic Outburst) syndrome, an autosomal dominant condition, present in approximately 25% of the population, where sneezing is provoked upon exposure to bright light. It is suggested that the anaesthesia induced by propofol may have sensitized patients with this condition to sneeze, since there appeared to be no other excitatory sequelae which have previously been described with propofol.
作者报告了一例病例，在球周阻滞采用丙泊酚镇静后，当局部麻醉针置入眶腔时诱发了打喷嚏。文中讨论了打喷嚏的生理学，以及常染色体显性强迫性光眼喷嚏发作（ACHOO）综合征的病理生理学，这是一种常染色体显性疾病，约25%的人群存在该疾病，即暴露于强光时会诱发打喷嚏。研究表明，丙泊酚诱导的麻醉可能使患有这种疾病的患者更容易打喷嚏，因为此前用丙泊酚并未描述过其他兴奋后遗症。
