Legras B, Gaudin M, Ruelland A, Cottencin M, Cloarec L
Ann Biol Clin (Paris). 1984;42(3):211-6.
243 cases of monoclonal immunoglobulinopathy were seen at the CHR in Rennes over a period of three years. The authors studied successively the relationship between the monoclonal immunoglobulin and the clinical diagnosis the distribution of the monoclonal compounds according to the heavy chain class and the identification of the light chains, the distribution of the immunoglobulinopathies in terms of the age and the sex of the patients and the correlation between the clinical diagnosis and various laboratory findings (proteins concentration, concentration of normal immunoglobulins, sedimentation rate...). The results obtained are in line with the principal data in the literature concerning monoclonal immunoglobulinopathies. However, the authors demonstrated, in the studied population, a higher percentage of monoclonal IgM than is usually reported. Furthermore, these IgM immunoglobulins, present in Waldenstrom's disease and frequently seen in various other immunoglobulinopathies, were essentially found in men.
在三年时间里，雷恩市的CHR共接诊了243例单克隆免疫球蛋白病患者。作者先后研究了单克隆免疫球蛋白与临床诊断之间的关系、单克隆化合物根据重链类别进行的分布以及轻链的鉴定、免疫球蛋白病在患者年龄和性别的分布情况，以及临床诊断与各种实验室检查结果（蛋白质浓度、正常免疫球蛋白浓度、血沉率等）之间的相关性。所获得的结果与文献中关于单克隆免疫球蛋白病的主要数据一致。然而，作者发现在所研究的人群中，单克隆IgM的比例高于通常报道的比例。此外，这些存在于华氏巨球蛋白血症中且在各种其他免疫球蛋白病中常见的IgM免疫球蛋白，主要在男性中发现。
