Berry T K, Flynn T C, Miller P W, Fischer R P
Ann Emerg Med. 1984 Oct;13(10):879-80. doi: 10.1016/s0196-0644(84)80660-5.
Coagulopathies such as dilutional coagulopathy secondary to massive crystalloid and/or blood resuscitation, and disseminated intravascular coagulation secondary to head injury, complicate the care of severely traumatized patients. The accuracy of diagnostic peritoneal lavage has not been appraised in patients with coagulopathy. During a 3-year period, 847 patients underwent diagnostic peritoneal lavage using the direct visualization, open method. Exploratory laparotomy was performed on 298 patients for a positive diagnostic peritoneal lavage. All patients had coagulation studies prior to diagnostic peritoneal lavage. Twenty-eight patients (9.4%) with a mean injury severity score of 45, had coagulopathy prior to diagnostic peritoneal lavage. Only 2% (6/298) of the diagnostic peritoneal lavages were falsely positive despite the presence of pelvic fractures in 24.5% (73/298) of the patients. The incidence of falsely positive diagnostic peritoneal lavage was similar (P = .5) for patients with coagulopathy (3.6%, 1/28) as compared to patients without coagulopathy (1.8%, 5/272). Following blunt trauma, clinical indications for diagnostic peritoneal lavage do not mandate coagulation screening because diagnostic peritoneal lavage is reliable in patients with preexisting coagulopathy.
凝血障碍,如大量晶体液和/或血液复苏继发的稀释性凝血障碍,以及头部损伤继发的弥散性血管内凝血,使严重创伤患者的治疗变得复杂。诊断性腹腔灌洗在凝血障碍患者中的准确性尚未得到评估。在3年期间,847例患者采用直接可视化开放法进行了诊断性腹腔灌洗。298例诊断性腹腔灌洗阳性患者接受了剖腹探查术。所有患者在诊断性腹腔灌洗前均进行了凝血检查。28例(9.4%)患者在诊断性腹腔灌洗前存在凝血障碍,平均损伤严重程度评分为45分。尽管24.5%(73/298)的患者存在骨盆骨折,但诊断性腹腔灌洗的假阳性率仅为2%(6/298)。与无凝血障碍的患者(1.8%,5/272)相比,凝血障碍患者诊断性腹腔灌洗的假阳性发生率相似(P = 0.5)(3.6%,1/28)。钝性创伤后,诊断性腹腔灌洗的临床指征并不要求进行凝血筛查,因为诊断性腹腔灌洗在已有凝血障碍的患者中是可靠的。