Moreno H R, Radomski J L
Cancer Lett. 1978 Feb;4(2):85-8. doi: 10.1016/s0304-3835(78)93632-7.
The glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl believed to be the carrier form responsible for transporting the active N-hydroxy compound from its site of formation in the liver to its site of carcinogenic action in the bladder has been prepared synthetically. The synthetic conjugate is identical by infrared and chromatographic analyses with the conjugate isolated from urine, thus unequivocally establishing its structure as an N--C conjugate, sodium (N,4-biphenyl-N-hydroxy-D-glucuronosylamine).
据信，N-羟基-4-氨基联苯的葡萄糖醛酸共轭物是负责将活性N-羟基化合物从其在肝脏中的形成部位运输到其在膀胱中的致癌作用部位的载体形式，现已通过合成制备出来。通过红外和色谱分析，合成的共轭物与从尿液中分离出的共轭物相同，从而明确确定其结构为N-C共轭物，即（N,4-联苯-N-羟基-D-葡萄糖醛酸胺）钠。
