3,2'-二甲基-4-氨基联苯（DMAB）在叙利亚金仓鼠和F344大鼠体内的代谢及其对器官亲和性的影响
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
作者信息
Nussbaum M, Fiala E S, Kulkarni B, El-Bayoumy K, Weisburger J H
出版信息
Environ Health Perspect. 1983 Mar;49:223-31. doi: 10.1289/ehp.8349223.
Abstract
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N-hydroxy-N-glucuronide of DMAB as a major metabolite in hamster urine and bile and in rat bile but not urine. The routes of excretion of this metabolite, which may represent a transport form of the ultimate carcinogen, correlate well with the main tumor sites in the two species. Other metabolites partially identified were the sulfates and glucuronides of C-hydroxylated DMAB and C-hydroxylated-N-acetyl DMAB.
摘要
在雄性叙利亚金仓鼠体内研究了氚标记的二甲基氨基联苯（DMAB）的代谢情况，该仓鼠对这种致癌物诱发的膀胱和肠道肿瘤均敏感；同时也在雄性F344大鼠体内进行了研究，在这种大鼠中肠道肿瘤是主要病变。有证据表明，DMAB的N-羟基-N-葡萄糖醛酸苷作为主要代谢产物存在于仓鼠尿液和胆汁以及大鼠胆汁中，但不存在于大鼠尿液中。这种代谢产物的排泄途径可能代表最终致癌物的一种转运形式，与这两个物种的主要肿瘤部位密切相关。部分鉴定出的其他代谢产物是C-羟基化DMAB和C-羟基化-N-乙酰基DMAB的硫酸盐和葡萄糖醛酸苷。
相似文献
1
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.3,2'-二甲基-4-氨基联苯（DMAB）在叙利亚金仓鼠和F344大鼠体内的代谢及其对器官亲和性的影响
Environ Health Perspect. 1983 Mar;49:223-31. doi: 10.1289/ehp.8349223.
2
The effect of disulfiram on the carcinogenicity of 3,2'dimethyl-4-aminopbiphenyl in Syrian golden hamsters and rats.双硫仑对叙利亚金仓鼠和大鼠中3,2'-二甲基-4-氨基联苯致癌性的影响。
Carcinogenesis. 1981;2(10):965-9. doi: 10.1093/carcin/2.10.965.
3
4
5
Effect of dietary wheat bran and dehydrated citrus fiber on 3,2'-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in F344 rats.日粮麦麸和脱水柑橘纤维对3,2'-二甲基-4-氨基联苯诱导的F344大鼠肠道癌变的影响。
Carcinogenesis. 1981;2(1):21-5. doi: 10.1093/carcin/2.1.21.
6
7
Formation of DNA adducts in vivo in rat liver and intestinal epithelium after administration of the carcinogen 3,2'-dimethyl-4-aminobiphenyl and its hydroxamic acid.给予致癌物3,2'-二甲基-4-氨基联苯及其异羟肟酸后，大鼠肝脏和肠上皮细胞体内DNA加合物的形成。
Carcinogenesis. 1985 Jan;6(1):37-44. doi: 10.1093/carcin/6.1.37.
8
Effect of acetylator genotype on 3,2'-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters.乙酰化酶基因型对3,2'-二甲基-4-氨基联苯诱导的仓鼠结肠异常隐窝病灶的影响。
Carcinogenesis. 1996 Mar;17(3):459-65. doi: 10.1093/carcin/17.3.459.
9
Histopathological analysis of invasive bladder carcinomas induced by 3,2'-dimethyl-4-aminobiphenyl in hamsters.3,2'-二甲基-4-氨基联苯诱导仓鼠发生浸润性膀胱癌的组织病理学分析。
Jpn J Cancer Res. 1996 Jan;87(1):37-43. doi: 10.1111/j.1349-7006.1996.tb00197.x.
10
Rat liver DNA damage by the non-hepatocarcinogen 3,2'-dimethyl-4-aminobiphenyl.非肝癌致癌物3,2'-二甲基-4-氨基联苯对大鼠肝脏DNA的损伤
Cancer Lett. 1984 Mar;22(2):211-8. doi: 10.1016/0304-3835(84)90121-6.
引用本文的文献
1
Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.在分子流行病学研究中杂环芳香胺的代谢和生物标志物：从芳香胺中吸取的经验教训。
Chem Res Toxicol. 2011 Aug 15;24(8):1169-214. doi: 10.1021/tx200135s. Epub 2011 Jun 20.
2
Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib.给予塞来昔布的大鼠结肠和肝脏中，3,2'-二甲基-4-氨基联苯衍生的DNA加合物呈剂量依赖性减少。
Mutat Res. 2008 Feb 1;638(1-2):103-9. doi: 10.1016/j.mrfmmm.2007.09.003. Epub 2007 Sep 14.
3
Histopathological analysis of invasive bladder carcinomas induced by 3,2'-dimethyl-4-aminobiphenyl in hamsters.3,2'-二甲基-4-氨基联苯诱导仓鼠发生浸润性膀胱癌的组织病理学分析。
Jpn J Cancer Res. 1996 Jan;87(1):37-43. doi: 10.1111/j.1349-7006.1996.tb00197.x.
4
DNA adducts in target and nontarget tissues of 3,2'-dimethyl-4-aminobiphenyl in rats.大鼠体内3,2'-二甲基-4-氨基联苯在靶组织和非靶组织中的DNA加合物
Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):167-72. doi: 10.1289/ehp.94102s6167.
5
Formation and persistence of arylamine DNA adducts in vivo.体内芳胺DNA加合物的形成与持久性。
Environ Health Perspect. 1985 Oct;62:19-30. doi: 10.1289/ehp.856219.
6
3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.3,2'-二甲基-4-氨基联苯诱导仓鼠胆囊致癌作用及炔雌醇的影响
Jpn J Cancer Res. 1992 Dec;83(12):1286-92. doi: 10.1111/j.1349-7006.1992.tb02760.x.
本文引用的文献
1
ENDEMIC AND MORPHOLOGIC SIMILARITIES EXISTING BETWEEN SPONTANEOUS COLONIC NEOPLASMS IN MAN AND 3:2'-DIMETHYL-4-AMINOBIPHENYL INDUCED COLONIC NEOPLASMS IN RATS.人类自发性结肠肿瘤与3:2'-二甲基-4-氨基联苯诱导的大鼠结肠肿瘤之间存在地方病学和形态学相似性。
Ann Surg. 1965 Feb;161(2):309-24. doi: 10.1097/00000658-196502000-00020.
2
Aromatic amines as carcinogens in industry.工业中作为致癌物的芳香胺。
Br Med Bull. 1958 May;14(2):141-5. doi: 10.1093/oxfordjournals.bmb.a069657.
3
Studies in detoxication. 71. The metabolism of hydroxycoumarins.解毒研究。71. 羟基香豆素的代谢
Biochem J. 1958 Jan;68(1):61-7. doi: 10.1042/bj0680061.
4
The biochemistry of aromatic amines. II. The conversion of arylamines into arylsulphamic acids and arylamine-N-glucosiduronic acids.芳香胺的生物化学。II. 芳胺转化为芳基氨基磺酸和芳胺 -N-葡萄糖醛酸。
Biochem J. 1957 Mar;65(3):417-23. doi: 10.1042/bj0650417a.
5
The carcinogenic action of 4-aminodiphenyl and 3:2'-dimethyl-4-amino-diphenyl.4-氨基二苯和3:2'-二甲基-4-氨基二苯的致癌作用。
Br J Ind Med. 1952 Oct;9(4):255-63. doi: 10.1136/oem.9.4.255.
6
Metabolism of o-[methyl-14C]toluidine in the F344 rat.F344大鼠中邻-[甲基-14C]甲苯胺的代谢
Xenobiotica. 1980 Jul-Aug;10(7-8):457-68. doi: 10.3109/00498258009033781.
7
The effect of disulfiram on the carcinogenicity of 3,2'dimethyl-4-aminopbiphenyl in Syrian golden hamsters and rats.双硫仑对叙利亚金仓鼠和大鼠中3,2'-二甲基-4-氨基联苯致癌性的影响。
Carcinogenesis. 1981;2(10):965-9. doi: 10.1093/carcin/2.10.965.
8
9
Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion.通过控制尿液pH值、抑制代谢性硫酸化以及改变胆汁排泄来改变大鼠尿液中致癌物N-羟基-2-萘胺及其N-葡萄糖醛酸苷的水平。
Chem Biol Interact. 1981 Jan;33(2-3):129-47. doi: 10.1016/0009-2797(81)90036-3.
Zotero 插件