Pardo V, Aldana M, Colton R M, Fischl M A, Jaffe D, Moskowitz L, Hensley G T, Bourgoignie J J
Ann Intern Med. 1984 Oct;101(4):429-34. doi: 10.7326/0003-4819-101-4-429.
Between January 1982 and December 1983, 75 patients with the acquired immunodeficiency syndrome were identified in our hospitals: 35% used intravenous drugs, 50% had proteinuria in excess of 0.5 g/dL, and 10% were nephrotic. Glomerular changes seen at autopsy in 36 patients included frequent mesangial lesions and deposits associated with mild asymptomatic proteinuria. Focal and segmental glomerular sclerosis was found in 5 patients and 4 of these had the nephrotic syndrome. Whereas reversible episodes of acute renal failure were not uncommon, terminal episodes of acute renal insufficiency occurred in 14 patients. The short survival of these patients may prevent the development of chronic renal failure.
1982年1月至1983年12月期间，我们医院共确诊了75例获得性免疫缺陷综合征患者：35%使用过静脉注射毒品，50%的患者蛋白尿超过0.5g/dL，10%为肾病患者。36例患者尸检时发现的肾小球改变包括常见的系膜病变和与轻度无症状蛋白尿相关的沉积物。5例患者发现局灶节段性肾小球硬化，其中4例患有肾病综合征。虽然急性肾衰竭的可逆性发作并不罕见，但14例患者出现了终末期急性肾功能不全。这些患者的短期生存可能会阻止慢性肾衰竭的发展。
