Akhtamova Z M, Abramova Z I, Voropaeva S D
Antibiotiki. 1984 Jun;29(6):456-60.
To determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim, assays of the patient urine and studies on the pharmacokinetics of the drugs were performed. The bacteriurea levels were estimated in 264 women with Gould's method in modification of Ryabinsky and Rodoman. The causative agents of the disease were isolated from the urine of 92 pregnant women. Sensitivity of the isolates to 9 antibiotics was tested with the use of standard paper disks and the method of serial dilutions in solid media. The pharmacokinetics of ampicillin and cephuroxim in the blood and urine of 97 patients was studied for 6-8 hours after parenteral administration of the antibiotics in doses of 500 mg. Comparative analysis of the pharmacokinetic parameters of the antibiotics in the blood and urine of the patients, the antibiotic MICs for the disease causative agents and the clinical course of the disease suggests that pyelonephritis gravidarum should be treated with ampicillin and cephuroxim on doses of 500 mg injected intramuscularly 4 and 3 times a day respectively for 7-8 days in combination with antiinflammatory therapy.
为确定氨苄西林和头孢呋辛治疗妊娠肾盂肾炎合理抗菌治疗的最佳方案，对患者尿液进行了检测，并对药物的药代动力学进行了研究。采用改良的Ryabinsky和Rodoman的Gould方法，对264名女性的菌尿水平进行了评估。从92名孕妇的尿液中分离出该病的病原体。使用标准纸片和固体培养基中的系列稀释法，检测分离株对9种抗生素的敏感性。在97名患者静脉注射500mg剂量抗生素后6 - 8小时，研究了氨苄西林和头孢呋辛在血液和尿液中的药代动力学。对患者血液和尿液中抗生素的药代动力学参数、疾病病原体的抗生素MIC值以及疾病的临床病程进行比较分析表明，妊娠肾盂肾炎应采用氨苄西林和头孢呋辛治疗，分别为500mg，每天肌肉注射4次和3次，共7 - 8天，并联合抗炎治疗。
