Akhtamova Z M, Khokholov L E, Dorokhov V V, Voropaeva S D
Antibiot Med Biotekhnol. 1985 Feb;30(2):124-8.
The pharmacokinetics of cefuroxime was studied in 40 pregnant women with acute pyelonephritis. The women were in the 2nd and 3rd terms of pregnancy. The antibiotic was injected in a dose of 500 mg. The antibiotic levels in the blood and urine were determined with the agar diffusion method. The pharmacokinetic parameters were measured in a one-compartmental model with regard to antibiotic absorption. The measurement was performed with the use of computer. The cefuroxime concentrations in the blood and urine were practically the same at all periods of the study and at different terms of pregnancy. In pregnant women with acute pyelonephritis, the volume of cefuroxime distribution and the time of a two-fold decrease in the blood antibiotic levels increased. The estimation of the optimal scheme of cefuroxime dosing by the Krueger-Timer principles provided treatment of acute pyelonephritis in pregnant women with intramuscular injections of the antibiotic in a dose of 500 mg every 8 hours for 7-8 days.
对40例患有急性肾盂肾炎的孕妇进行了头孢呋辛的药代动力学研究。这些孕妇处于妊娠中期和晚期。以500毫克的剂量注射抗生素。采用琼脂扩散法测定血液和尿液中的抗生素水平。在单室模型中测量抗生素吸收方面的药代动力学参数。测量通过计算机进行。在研究的所有阶段以及不同妊娠时期，血液和尿液中的头孢呋辛浓度实际上是相同的。在患有急性肾盂肾炎的孕妇中，头孢呋辛的分布容积以及血液中抗生素水平降低一半的时间增加。根据克鲁格 - 蒂默原理估算头孢呋辛给药的最佳方案，为患有急性肾盂肾炎的孕妇提供了治疗方法，即每8小时肌肉注射500毫克抗生素，持续7 - 8天。
