Munger D, Sternson L A, Patton T F
Cancer Treat Rep. 1978 Mar;62(3):409-12.
The distribution of dianhydrogalactitol-C14 (DAG-C14) which had been administered to rats as an iv bolus injection was studied in plasma and brain tissue. Analysis of samples was carried out by a high-pressure liquid chromatography method which specifically responds to the parent drug. Samples were monitored by both ultraviolet and liquid scintillation spectrometry. Plasma level measurements indicate that intact DAG has a relatively short half-life in plasma (t1/2= 43.7 minutes) and brain (t1/2 = 50.3 minutes). These findings differ significantly from those studies which have measured total radioactivity when monitoring DAG levels; and should be considered in the design of DAG dose regiments. Data from both brain and plasma were consistent with a classic two-compartment open model.
研究了以静脉推注方式给予大鼠的双脱水半乳糖醇 - C14（DAG - C14）在血浆和脑组织中的分布情况。采用对母体药物有特异性反应的高压液相色谱法对样本进行分析。通过紫外光谱法和液体闪烁光谱法对样本进行监测。血浆水平测量表明，完整的DAG在血浆中的半衰期相对较短（t1/2 = 43.7分钟），在脑内的半衰期为（t1/2 = 50.3分钟）。这些发现与那些在监测DAG水平时测量总放射性的研究结果有显著差异；在设计DAG给药方案时应予以考虑。来自脑和血浆的数据均符合经典的二室开放模型。
