Eckhardt S, Csetényi J, Horváth I P, Kerpel-Fronius S, Számel I, Institóris L, Szlovik F, Pásztor E, Afra D
Cancer Treat Rep. 1977 Aug;61(5):841-7.
The distribution of iv administered 3H-dianhydrogalactitol (DAG) in the plasma, cerebrospinal fluid (CSF), brain, and tumor tissue was studied in 11 patients. DAG entered the CSF and was slowly eliminated, with a half-life of 20 hours. Unchanged DAG accounted for about 6%-30% of the total radioactivity in the CSF. All the tumors accumulated the drug to a higher extent than the intact white matter, except the one meningioma studied. The highest uptake was observed in the relatively benign astrocytic tumors.
对11例患者静脉注射3H-双脱水半乳糖醇（DAG）后在血浆、脑脊液（CSF）、脑和肿瘤组织中的分布进行了研究。DAG进入脑脊液并缓慢消除，半衰期为20小时。未变化的DAG约占脑脊液中总放射性的6%-30%。除所研究的1例脑膜瘤外，所有肿瘤对药物的蓄积程度均高于完整白质。在相对良性的星形细胞瘤中观察到最高摄取量。
